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Tohoku Univ. Technology：Lubiprostone, a constipation drug, has a kidney protective effect：T25-005

Tohoku Univ. Technology：Lubiprostone, a constipation drug, has a kidney protective effect：T25-005

Improvement of Intestinal Microbiota Improves Mitochondrial Function

Chronic kidney disease (CKD) is a major global health issue without any drugs that improve kidney function. Previous mouse experiments showed that lubiprostone, a constipation drug, reduces uremic toxin accumulation by improving the intestinal environment altered by kidney decline, thus inhibiting kidney damage progression 1. A phase II clinical trial was conducted to test lubiprostone's effects on kidney function in patients. Results revealed dose-dependent suppression of kidney function decline (eGFR) in lubiprostone-treated patients compared to placebo. Further analysis showed lubiprostone improves kidney mitochondrial function by modulating the gut microbiota and increasing spermidine production, which enhances mitochondrial activity and provides kidney protection.

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[Research Material] The Global Market for Constipation Treatment

[Research Material] The Global Market for Constipation Treatment

Global Market for Constipation Treatment: Chronic Idiopathic Constipation, Constipation Associated with Irritable Bowel Syndrome, Opioid-Induced Constipation, Hospital Pharmacies, Retail Pharmacies, Online Pharmacies

This research report (Global Constipation Treatment Market) investigates and analyzes the current state and outlook for the global constipation treatment market over the next five years. It includes information on the overview of the global constipation treatment market, trends of major companies (sales, selling prices, market share), market size by segment, market size by major regions, and distribution channel analysis. The segments by type in the constipation treatment market focus on chronic idiopathic constipation, constipation associated with irritable bowel syndrome, and opioid-induced constipation, while the segments by application target hospital pharmacies, retail pharmacies, and online pharmacies. The regional segments calculate the market size for constipation treatment by dividing it into North America, the United States, Europe, Asia-Pacific, Japan, China, India, South Korea, Southeast Asia, South America, the Middle East, and Africa. The report also includes the market share of major companies in the constipation treatment sector, product and business overviews, and sales performance.

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